Product overview:

IL6R mouse monoclonal antibody, clone LBI2F4

Field of research:

Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

Summary:

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2011]

Alternative names:

CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ

Species reactivity:

Human

Host:

Mouse

Target:

IL6R

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human IL6R(NP_000556) produced in HEK293T cell.

Clone:

LBI2F4

Conjugation:

Unconjugated

Gene name:

interleukin 6 receptor

Symbol:

IL6R

Pathway:

Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

Function:

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:4000, IHC 1:150, IF 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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