Product overview:

Carrier-free (BSA/glycerol-free) CYP7B1 mouse monoclonal antibody,clone LBI1G7

Field of research:

Primary bile acid biosynthesis

Summary:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. [provided by RefSeq, Jul 2008]

Alternative names:

CBAS3; CP7B; SPG5A

Species reactivity:

Human

Host:

Mouse

Target:

CYP7B1

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 263-506 of human CYP7B1 (NP_004811) produced in E.coli.

Clone:

LBI1G7

Conjugation:

Unconjugated

Gene name:

Homo sapiens cytochrome P450 family 7 subfamily B member 1 (CYP7B1), transcript variant 1, mRNA.

Symbol:

CYP7B1

Pathway:

Primary bile acid biosynthesis

Function:

Druggable Genome, P450, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:500, IHC 1:500

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com