Product overview:

Carrier-free (BSA/glycerol-free) ACVR2A mouse monoclonal antibody,clone LBI1F2

Field of research:

Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

Summary:

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

Alternative names:

ACTRII; ACVR2

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

ACVR2A

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 214-513 of human ACVR2A(NP_001607) produced in E.coli.

Clone:

LBI1F2

Conjugation:

Unconjugated

Gene name:

Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA.

Symbol:

ACVR2A

Pathway:

Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

Function:

Druggable Genome, Protein Kinase, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:500, IHC 1:2000

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com