Product overview:

Carrier-free (BSA/glycerol-free) C2 mouse monoclonal antibody,clone LBI1A7

Field of research:

Complement and coagulation cascades, Systemic lupus erythematosus

Summary:

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined. [provided by RefSeq, Mar 2009]

Alternative names:

ARMD14; CO2

Species reactivity:

Human

Host:

Mouse

Target:

C2

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 469-752 of human C2(NP_000054) produced in E.coli.

Clone:

LBI1A7

Conjugation:

Unconjugated

Gene name:

Homo sapiens complement C2 (C2), transcript variant 1, mRNA.

Symbol:

C2

Pathway:

Complement and coagulation cascades, Systemic lupus erythematosus

Function:

Druggable Genome, Protease, Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:500, IHC 1:150

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com