Product overview:

Carrier-free (BSA/glycerol-free) VRK1 mouse monoclonal antibody, clone LBI2E10

Field of research:

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Summary:

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]

Alternative names:

PCH1; PCH1A

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

VRK1

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 1-230 of human VRK1(NP_003375) produced in E.coli.

Clone:

LBI2E10

Conjugation:

Unconjugated

Gene name:

Homo sapiens VRK serine/threonine kinase 1 (VRK1), mRNA.

Symbol:

VRK1

Pathway:

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Function:

Druggable Genome, Protein Kinase

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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