Product overview:

Carrier-free (BSA/glycerol-free) PRKD3 mouse monoclonal antibody, clone LBI4G6

Field of research:

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Summary:

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq, Jul 2008]

Alternative names:

EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PRKD3

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 300-508 of human PRKD3 (NP_005804) produced in E.coli.

Clone:

LBI4G6

Conjugation:

Unconjugated

Gene name:

Homo sapiens protein kinase D3 (PRKD3), mRNA.

Symbol:

PRKD3

Pathway:

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Function:

Druggable Genome, Protein Kinase

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:500, IHC 1:150

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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