Product overview:

Carrier-free (BSA/glycerol-free) APOE mouse monoclonal antibody, clone LBI1E6

Field of research:

Alzheimer's disease

Summary:

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008]

Alternative names:

AD2; APO-E; LDLCQ5; LPG

Species reactivity:

Human

Host:

Mouse

Target:

APOE

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human APOE (NP_000032) produced in HEK293T cell.

Clone:

LBI1E6

Conjugation:

Unconjugated

Gene name:

Homo sapiens apolipoprotein E (APOE), transcript variant 2, mRNA.

Symbol:

APOE

Pathway:

Alzheimer's disease

Function:

Adult stem cells, Druggable Genome, Secreted Protein, Stem cell - Pluripotency

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:200, IHC 1:150

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com