Product overview:

Carrier-free (BSA/glycerol-free) AGT mouse monoclonal antibody, clone LBI10D2

Field of research:

Renin-angiotensin system

Summary:

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

Alternative names:

ANHU; SERPINA8

Species reactivity:

Human

Host:

Mouse

Target:

AGT

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 34-331 of human AGT (NP_000020) produced in E.coli.

Clone:

LBI10D2

Conjugation:

Unconjugated

Gene name:

Homo sapiens angiotensinogen (AGT), mRNA.

Symbol:

AGT

Pathway:

Renin-angiotensin system

Function:

Druggable Genome, Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:500

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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