Product overview:

Carrier-free (BSA/glycerol-free) MAPKAPK5 mouse monoclonal antibody, clone LBI1A7

Field of research:

MAPK signaling pathway

Summary:

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov

Alternative names:

MAPKAP-K5; MK-5; MK5; PRAK

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

MAPKAPK5

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 197-471 of human MAPKAPK5 (NP_003659) produced in E.coli.

Clone:

LBI1A7

Conjugation:

Unconjugated

Gene name:

Homo sapiens MAPK activated protein kinase 5 (MAPKAPK5), transcript variant 1, mRNA.

Symbol:

MAPKAPK5

Pathway:

MAPK signaling pathway

Function:

Druggable Genome, Protein Kinase

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com