Product overview:

OX40(TNFRSF4) mouse monoclonal antibody,clone UMLBI277

Field of research:

Cytokine-cytokine receptor interaction

Summary:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

Alternative names:

ACT35; CD134; IMD16; OX40; TXGP1L

Species reactivity:

Human

Host:

Mouse

Target:

TNFRSF4

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human TNFRSF4 (NP_003318) produced in HEK293T cell.

Clone:

UMLBI277

Conjugation:

Unconjugated

Gene name:

Homo sapiens TNF receptor superfamily member 4 (TNFRSF4), mRNA.

Symbol:

TNFRSF4

Pathway:

Cytokine-cytokine receptor interaction

Function:

Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.5~1.0 mg/ml (Lot Dependent)

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

IHC 1:50~100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com