Product overview:

MSH2 mouse monoclonal antibody,clone UMLBI259

Field of research:

Colorectal cancer, Mismatch repair, Pathways in cancer

Summary:

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Alternative names:

COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; MMRCS2

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

MSH2

Isotype:

IgG2b

Immunogen:

Human recombinant protein fragment corresponding to amino acids 1-304 of human MSH2 (NP_000242) produced in E.coli.

Clone:

UMLBI259

Conjugation:

Unconjugated

Gene name:

Homo sapiens mutS homolog 2 (MSH2), transcript variant 1, mRNA.

Symbol:

MSH2

Pathway:

Colorectal cancer, Mismatch repair, Pathways in cancer

Function:

Druggable Genome, Stem cell - Pluripotency

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.5~1.0 mg/ml (Lot Dependent)

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

IHC 1:2400

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com