Product overview:

UBA7 mouse monoclonal antibody,clone LBI2B6

Field of research:

Parkinson's disease, Ubiquitin mediated proteolysis

Summary:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]

Alternative names:

D8; UBA1B; UBE1L; UBE2

Species reactivity:

Human

Host:

Mouse

Target:

UBA7

Isotype:

IgG2b

Immunogen:

Full length human recombinant protein of human UBA7 (NP_003326) produced in HEK293T cell.

Clone:

LBI2B6

Conjugation:

Unconjugated

Gene name:

ubiquitin like modifier activating enzyme 7

Symbol:

UBA7

Pathway:

Parkinson's disease, Ubiquitin mediated proteolysis

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500~2000, IHC 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com