Product overview:

PTPN22 mouse monoclonal antibody,clone LBI6B1

Field of research:

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Summary:

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]

Alternative names:

LYP; LYP1; LYP2; PEP; PTPN8

Species reactivity:

Human

Host:

Mouse

Target:

PTPN22

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 359-449 of human PTPN22 (NP_057051) produced in E.coli.

Clone:

LBI6B1

Conjugation:

Unconjugated

Gene name:

protein tyrosine phosphatase, non-receptor type 22

Symbol:

PTPN22

Pathway:

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Function:

Druggable Genome, Phosphatase

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:1000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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