Product overview:

ALPL mouse monoclonal antibody,clone LBI3A1

Field of research:

Folate biosynthesis, Metabolic pathways

Summary:

This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]

Alternative names:

AP-TNAP; APTNAP; HOPS; TNAP; TNSALP

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

ALPL

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human ALPL (NP_000469) produced in HEK293T cell.

Clone:

LBI3A1

Conjugation:

Unconjugated

Gene name:

alkaline phosphatase, liver/bone/kidney

Symbol:

ALPL

Pathway:

Folate biosynthesis, Metabolic pathways

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com