Product overview:

MYBPC3 mouse monoclonal antibody, clone LBI2D7

Field of research:

Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

Summary:

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Alternative names:

CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C

Species reactivity:

Human

Host:

Mouse

Target:

MYBPC3

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human MYBPC3（C0-C1） (NP_000247) produced in E.coli.

Clone:

LBI2D7

Conjugation:

Unconjugated

Gene name:

myosin binding protein C, cardiac

Symbol:

MYBPC3

Pathway:

Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

ELISA 1:5000-10000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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