Product overview:

PRG2 mouse monoclonal antibody,clone LBI2F11

Field of research:

Asthma

Summary:

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Alternative names:

BMPG; MBP; MBP1; proMBP

Species reactivity:

Human

Host:

Mouse

Target:

PRG2

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 17-222 of human PRG2 (NP_002719) produced in E.coli.

Clone:

LBI2F11

Conjugation:

Unconjugated

Gene name:

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

Symbol:

PRG2

Pathway:

Asthma

Function:

Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com