Product overview:

CTSL mouse monoclonal antibody,clone LBI1C7

Field of research:

Antigen processing and presentation, Lysosome

Summary:

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Alternative names:

CATL; CTSL1; MEP

Species reactivity:

Human

Host:

Mouse

Target:

CTSL

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 114-333 of human CTSL (NP_001903) produced in E.coli.

Clone:

LBI1C7

Conjugation:

Unconjugated

Gene name:

cathepsin L

Symbol:

CTSL

Pathway:

Antigen processing and presentation, Lysosome

Function:

Druggable Genome, Protease

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500, IHC 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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