Product overview:

CAV1 mouse monoclonal antibody,clone LBI2C4

Field of research:

Focal adhesion, Viral myocarditis

Summary:

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1. [provided by RefSeq, Mar 2010]

Alternative names:

BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

CAV1

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 2-104 of human CAV1 (NP_001744) produced in E.coli.

Clone:

LBI2C4

Conjugation:

Unconjugated

Gene name:

caveolin 1

Symbol:

CAV1

Pathway:

Focal adhesion, Viral myocarditis

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500, IHC 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com