Product overview:

MTHFR mouse monoclonal antibody,clone LBI4C5

Field of research:

Metabolic pathways, Methane metabolism, One carbon pool by folate

Summary:

The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. [provided by RefSeq, Oct 2009]

Alternative names:

5,10-methylenetetrahydrofolate reductase (NADPH); methylenetetrahydrofolate reductase intermediate form; OTTHUMP00000002367; OTTHUMP00000002368

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

MTHFR

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 1-230 of human MTHFR (NP_005948) produced in E.coli.

Clone:

LBI4C5

Conjugation:

Unconjugated

Gene name:

methylenetetrahydrofolate reductase (NAD(P)H)

Symbol:

MTHFR

Pathway:

Metabolic pathways, Methane metabolism, One carbon pool by folate

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com