Product overview:

NEDD4 mouse monoclonal antibody,clone LBI5A8

Field of research:

Endocytosis, Ubiquitin mediated proteolysis

Summary:

This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

Alternative names:

NEDD4-1; RPF1

Species reactivity:

Human

Host:

Mouse

Target:

NEDD4

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 160-460 of human NEDD4 (NP_940682) produced in E.coli.

Clone:

LBI5A8

Conjugation:

Unconjugated

Gene name:

neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

Symbol:

NEDD4

Pathway:

Endocytosis, Ubiquitin mediated proteolysis

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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