Product overview:

ARRB1 mouse monoclonal antibody, clone LBI2B3

Field of research:

Chemokine signaling pathway, Endocytosis, MAPK signaling pathway

Summary:

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011].

Alternative names:

ARB1; ARR1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

ARRB1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human ARRB1 (NP_004032) produced in E.coli.

Clone:

LBI2B3

Conjugation:

Unconjugated

Gene name:

arrestin beta 1

Symbol:

ARRB1

Pathway:

Chemokine signaling pathway, Endocytosis, MAPK signaling pathway

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500-2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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