Product overview:

MASP2 mouse monoclonal antibody,clone LBI5C4

Field of research:

Complement and coagulation cascades

Summary:

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Alternative names:

MAP-2; MAP19; MASP-2; MASP1P1; sMAP

Species reactivity:

Human

Host:

Mouse

Target:

MASP2

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 445-686 of human MASP2 (NP_006601) produced in E.coli.

Clone:

LBI5C4

Conjugation:

Unconjugated

Gene name:

mannan binding lectin serine peptidase 2

Symbol:

MASP2

Pathway:

Complement and coagulation cascades

Function:

Druggable Genome, Protease, Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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