Product overview:

F2 mouse monoclonal antibody,clone LBI5B11

Field of research:

Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton

Summary:

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Alternative names:

PT; RPRGL2; THPH1

Species reactivity:

Human

Host:

Mouse

Target:

F2

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 44-622 of human F2 (NP_000497) produced in HEK293T cell.

Clone:

LBI5B11

Conjugation:

Unconjugated

Gene name:

coagulation factor II, thrombin

Symbol:

F2

Pathway:

Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton

Function:

Druggable Genome, Protease, Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com