Product overview:

GRB10 mouse monoclonal antibody,clone LBI5A6

Field of research:

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Summary:

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

Alternative names:

Grb-10; GRB-IR; IRBP; MEG1; RSS

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

GRB10

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 164-415 of human GRB10 (NP_005302) produced in E.coli.

Clone:

LBI5A6

Conjugation:

Unconjugated

Gene name:

growth factor receptor bound protein 10

Symbol:

GRB10

Pathway:

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Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500, IHC 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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