Product overview:

IL2RB mouse monoclonal antibody,clone LBI1B5

Field of research:

Cytokine-cytokine receptor interaction, Endocytosis, Jak-STAT signaling pathway

Summary:

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]

Alternative names:

CD122; IL15RB; P70-75

Species reactivity:

Human

Host:

Mouse

Target:

IL2RB

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 27-240+Mouse FC of human IL2RB (NP_000869) produced in HEK293T cell.

Clone:

LBI1B5

Conjugation:

Unconjugated

Gene name:

interleukin 2 receptor subunit beta

Symbol:

IL2RB

Pathway:

Cytokine-cytokine receptor interaction, Endocytosis, Jak-STAT signaling pathway

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com