Product overview:

ACE mouse monoclonal antibody,clone LBI2G5

Field of research:

Hypertrophic cardiomyopathy (HCM), Renin-angiotensin system

Summary:

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

Alternative names:

ACE1; CD143; DCP; DCP1

Species reactivity:

Human

Host:

Mouse

Target:

ACE

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 642-1230 of human ACE (NP_000780) produced in E.coli.

Clone:

LBI2G5

Conjugation:

Unconjugated

Gene name:

angiotensin I converting enzyme

Symbol:

ACE

Pathway:

Hypertrophic cardiomyopathy (HCM), Renin-angiotensin system

Function:

Druggable Genome, ES Cell Differentiation/IPS, Protease, Secreted Protein, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500, IHC 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com