Product overview:

CIITA mouse monoclonal antibody,clone LBI7B12

Field of research:

Antigen processing and presentation, Primary immunodeficiency

Summary:

This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Alternative names:

C2TA; CIITAIV; MHC2TA; NLRA

Species reactivity:

Human

Host:

Mouse

Target:

CIITA

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 414-724 of human CIITA (NP_000237) produced in E.coli.

Clone:

LBI7B12

Conjugation:

Unconjugated

Gene name:

class II, major histocompatibility complex, transactivator

Symbol:

CIITA

Pathway:

Antigen processing and presentation, Primary immunodeficiency

Function:

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Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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