Product overview:

SERPINI1 mouse monoclonal antibody,clone LBI1A5

Field of research:

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Summary:

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Alternative names:

HNS-S1; HNS-S2; neuroserpin; PI12

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

SERPINI1

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 17-410 of human SERPINI1 (NP_005016) produced in E.coli.

Clone:

LBI1A5

Conjugation:

Unconjugated

Gene name:

serpin family I member 1

Symbol:

SERPINI1

Pathway:

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Function:

Druggable Genome, Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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