Product overview:

COX17 mouse monoclonal antibody,clone LBI2D7

Field of research:

Metabolic pathways, Oxidative phosphorylation

Summary:

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]

Alternative names:

MGC104397; MGC117386

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

COX17

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 2-63 of human COX17 (NP_005685) produced in E.coli.

Clone:

LBI2D7

Conjugation:

Unconjugated

Gene name:

COX17 cytochrome c oxidase copper chaperone

Symbol:

COX17

Pathway:

Metabolic pathways, Oxidative phosphorylation

Function:

Request info at info@sobekbio.com

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com