Product overview:

PCSK9 mouse monoclonal antibody,clone LBI8C12

Field of research:

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Summary:

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Alternative names:

FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9

Species reactivity:

Human

Host:

Mouse

Target:

PCSK9

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 153-692 of human PCSK9 (NP_777596) produced in E.coli.

Clone:

LBI8C12

Conjugation:

Unconjugated

Gene name:

proprotein convertase subtilisin/kexin type 9

Symbol:

PCSK9

Pathway:

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Function:

Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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