Product overview:

TNFSF10 mouse monoclonal antibody,clone LBI9A8

Field of research:

Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

Summary:

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Alternative names:

Apo-2L; APO2L; CD253; TL2; TRAIL

Species reactivity:

Human

Host:

Mouse

Target:

TNFSF10

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 39-281 of human TNFSF10 (NP_003801) produced in E.coli.

Clone:

LBI9A8

Conjugation:

Unconjugated

Gene name:

tumor necrosis factor superfamily member 10

Symbol:

TNFSF10

Pathway:

Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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