Product overview:

CYP26B1 mouse monoclonal antibody,clone LBI4A8

Field of research:

Retinol metabolism

Summary:

This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Alternative names:

CYP26A2; P450RAI-2; P450RAI2; RHFCA

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

CYP26B1

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 229-512 of human CYP26B1 (NP_063938) produced in E.coli.

Clone:

LBI4A8

Conjugation:

Unconjugated

Gene name:

cytochrome P450 family 26 subfamily B member 1

Symbol:

CYP26B1

Pathway:

Retinol metabolism

Function:

Druggable Genome, P450

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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