Product overview:

BRCC3 mouse monoclonal antibody,clone LBI6G7

Field of research:

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Summary:

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]

Alternative names:

BRCC36; C6.1A; CXorf53

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

BRCC3

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 41-316 of human BRCC3 (NP_077308) produced in E.coli.

Clone:

LBI6G7

Conjugation:

Unconjugated

Gene name:

BRCA1/BRCA2-containing complex subunit 3

Symbol:

BRCC3

Pathway:

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Function:

Druggable Genome, Protease

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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