Product overview:

IMPDH2 mouse monoclonal antibody,clone LBI2F10

Field of research:

Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

Summary:

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

Alternative names:

IMPD2; IMPDH-II

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

IMPDH2

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human IMPDH2 (NP_000875) produced in HEK293T cell.

Clone:

LBI2F10

Conjugation:

Unconjugated

Gene name:

IMP (inosine 5'-monophosphate) dehydrogenase 2

Symbol:

IMPDH2

Pathway:

Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com