Product overview:

GCH1 mouse monoclonal antibody,clone LBI5A1

Field of research:

Folate biosynthesis, Metabolic pathways

Summary:

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]

Alternative names:

DYT5; DYT5a; DYT14; GCH; GTP-CH-1; GTPCH1; HPABH4B

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

GCH1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human GCH1 (NP_001019195) produced in E.coli.

Clone:

LBI5A1

Conjugation:

Unconjugated

Gene name:

GTP cyclohydrolase 1

Symbol:

GCH1

Pathway:

Folate biosynthesis, Metabolic pathways

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com