Product overview:

AANAT mouse monoclonal antibody,clone LBI6E1

Field of research:

Metabolic pathways, Tryptophan metabolism

Summary:

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Alternative names:

DSPS; SNAT

Species reactivity:

Human

Host:

Mouse

Target:

AANAT

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 1-72 of human AANAT (NP_001079) produced in E.coli.

Clone:

LBI6E1

Conjugation:

Unconjugated

Gene name:

aralkylamine N-acetyltransferase

Symbol:

AANAT

Pathway:

Metabolic pathways, Tryptophan metabolism

Function:

Request info at info@sobekbio.com

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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