Product overview:

MAPK8IP1 mouse monoclonal antibody,clone LBI13F10

Field of research:

MAPK signaling pathway

Summary:

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

Alternative names:

IB1; JIP-1; JIP1; PRKM8IP

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

MAPK8IP1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human MAPK8IP1 (NP_005447) produced in HEK293T cell.

Clone:

LBI13F10

Conjugation:

Unconjugated

Gene name:

mitogen-activated protein kinase 8 interacting protein 1

Symbol:

MAPK8IP1

Pathway:

MAPK signaling pathway

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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