Product overview:

SIRT1 mouse monoclonal antibody,clone LBI12H3

Field of research:

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Summary:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Alternative names:

SIR2; SIR2alpha; SIR2L1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

SIRT1

Isotype:

IgG2b

Immunogen:

Human recombinant protein fragment corresponding to amino acids 552-676 of human SIRT1(NP_036370) produced in E.coli.

Clone:

LBI12H3

Conjugation:

Unconjugated

Gene name:

sirtuin 1

Symbol:

SIRT1

Pathway:

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Function:

Druggable Genome, Stem cell - Pluripotency, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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