Product overview:

TIMM8A mouse monoclonal antibody,clone LBI5C8

Field of research:

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Summary:

This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2009]

Alternative names:

DDP; DDP1; DFN1; MTS; TIM8

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

TIMM8A

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human TIMM8A (NP_004076) produced in E.coli.

Clone:

LBI5C8

Conjugation:

Unconjugated

Gene name:

translocase of inner mitochondrial membrane 8 homolog A (yeast)

Symbol:

TIMM8A

Pathway:

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Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500~2000, IHC 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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