Product overview:

IL24 mouse monoclonal antibody,clone LBI4H4

Field of research:

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Summary:

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Alternative names:

C49A; FISP; IL10B; MDA7; MOB5; ST16

Species reactivity:

Human

Host:

Mouse

Target:

IL24

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 52-206 of human IL24(NP_006841) produced in E.coli.

Clone:

LBI4H4

Conjugation:

Unconjugated

Gene name:

interleukin 24

Symbol:

IL24

Pathway:

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Function:

Druggable Genome, Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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