Product overview:

DUSP4 mouse monoclonal antibody,clone LBI7C11

Field of research:

MAPK signaling pathway

Summary:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]

Alternative names:

HVH2; MKP-2; MKP2; TYP

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

DUSP4

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 1-257 of human DUSP4(NP_476499) produced in E.coli.

Clone:

LBI7C11

Conjugation:

Unconjugated

Gene name:

dual specificity phosphatase 4

Symbol:

DUSP4

Pathway:

MAPK signaling pathway

Function:

Phosphatase

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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