Product overview:

Carrier-free (BSA/glycerol-free) PDE4B mouse monoclonal antibody, clone LBI1D12

Field of research:

Progesterone-mediated oocyte maturation, Purine metabolism

Summary:

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Alternative names:

DPDE4; PDE4B5; PDEIVB

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PDE4B

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human PDE4B(NP_002591) produced in HEK293T cell.

Clone:

LBI1D12

Conjugation:

Unconjugated

Gene name:

Homo sapiens phosphodiesterase 4B (PDE4B), transcript variant a, mRNA.

Symbol:

PDE4B

Pathway:

Progesterone-mediated oocyte maturation, Purine metabolism

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com