Product overview:

Carrier-free (BSA/glycerol-free) CCM2 mouse monoclonal antibody, clone LBI2E4

Field of research:

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Summary:

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names:

C7orf22; OSM; PP10187

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

CCM2

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell.

Clone:

LBI2E4

Conjugation:

Unconjugated

Gene name:

Homo sapiens CCM2 scaffold protein (CCM2), transcript variant 2, mRNA.

Symbol:

CCM2

Pathway:

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Function:

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Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000, IHC 1:150, IF 1:100

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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