Product overview:

Carrier-free (BSA/glycerol-free) BTK mouse monoclonal antibody, clone LBI10E10

Field of research:

B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency

Summary:

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.

Alternative names:

AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

BTK

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human BTK (NP_000052) produced in HEK293T cell.

Clone:

LBI10E10

Conjugation:

Unconjugated

Gene name:

Homo sapiens Bruton tyrosine kinase (BTK), transcript variant 1, mRNA.

Symbol:

BTK

Pathway:

B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency

Function:

Druggable Genome, Protein Kinase

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000, IHC 1:50, IF 1:100

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com