Product overview:

Carrier-free (BSA/glycerol-free) HSD17B10 mouse monoclonal antibody, clone LBI10B4

Field of research:

Alzheimer's disease, Metabolic pathways, Valine, leucine and isoleucine degradation

Summary:

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Alternative names:

17b-HSD10; ABAD; CAMR; DUPXp11.22; ERAB; HADH2; HCD2; MHBD; MRPP2; MRX17; MRX31; MRXS10; SCHAD

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

HSD17B10

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human HSD17B10(NP_004484) produced in HEK293T cell.

Clone:

LBI10B4

Conjugation:

Unconjugated

Gene name:

Homo sapiens hydroxysteroid 17-beta dehydrogenase 10 (HSD17B10), transcript variant 1, mRNA.

Symbol:

HSD17B10

Pathway:

Alzheimer's disease, Metabolic pathways, Valine, leucine and isoleucine degradation

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:1000, IHC 1:50, IF 1:100, Flow 1:100

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com