Furazolidone Metabolite Derivative SMAG3107

species: - Concentration: 1mg/ml -Applications: WB; ELISA; Immunogen; POCT -Tag: BSA; OVA; HRP Product Description: This product is supplied with multiple conjugates: BSA/OVA/HRP - CAS Number: 67-45-8 - Alias: Furazol; Furazolidine; Furazolidone; Furoxone; Nifurazolidone; 67-45-8 -Molecular FormulaC8H7N3O5 Background: Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone has been shown to exhibit antibiotic and anti-microbial functions. Furazolidone is also used as a poultry food additive. It is marketed by Roberts Laboratories under the brand name Furoxone and by GlaxoSmithKline as Dependal-M. Furoxone has a broad antibacterial spectrum covering the majority of gastrointestinal tract pathogens including E. coli, staphylococci, Salmonella, Shigella, Proteus, Aerobacter aerogenes, Vibrio cholerae and Giardia lamblia. Its bactericidal activity is based upon its interference with DNA replication and protein production. Furazolidone binds bacterial DNA which leads to the gradual inhibition of monoamine oxidase (From Martindale, The Extra Pharmacopoeia, 30th ed, p514). Furazolidone and its related free radical products are believed to bind DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug leading to high levels of mutations (transitions and transversions) in the bacterial chromosome. Furazolidone belongs to the family of Nitrofurans. These are compounds containing a furan ring which bears a nitro group.