Background:

Phosphatidylinositol 3-kinase (PI3K) plays an important role in the metabolic actions of insulin and is required for adipogenesis. The PI3K pathway has also been identified as an important player in cancer development and progression. The Class IA PI3K heterodimer, which is composed of a P110 catalytic subunit and a P85 regulatory subunit, is activated upon association of the P85 subunit with upstream adaptor proteins or receptor tyrosine kinases. Mutations in PIK3R1 are implicated in cases of breast cancer and associated to SHORT syndrome.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

MPPH, MPPH1, P85B, p85, p85-BETA, PIK3R2, PI3-kinase regulatory subunit beta, PI3K regulatory subunit beta, PI3-kinase subunit p85-beta, PtdIns-3-kinase regulatory subunit p85-beta

Specificity:

Human, rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Phosphatidylinositol 3-kinase regulatory subunit beta

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

81 kDa, 100 kDa

Form:

liquid

Applications:

ELISA, WB

Recommended dilution:

WB: 1:500-1:2000

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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