Background:

NPPB, also known as B-type natriuretic peptide (BNP), is a cardiac hormone that is secreted mainly in the ventricles in response to increased wall stress. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. BNP is a marker of systolic and diastolic dysfunction and a strong predictor of mortality in heart failure patients.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

BNP, BNP(1 32), Natriuretic peptides B, NPPB

Specificity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

natriuretic peptide precursor B

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

15 kDa

Form:

liquid

Applications:

ELISA, IHC

Recommended dilution:

IHC: 1:20-1:200

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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