Background:

mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element(ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation(PubMed:14981510). Specifically expressed in burst-forming unit-erythroid(BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation(By similarity).

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

BRF2, Butyrate response factor 2, EGF response factor 2, ERF 2, ERF2, Protein TIS11D, RNF162C, TIS11D, ZFP36L2

Specificity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

zinc finger protein 36, C3H type-like 2

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

51 kDa

Form:

liquid

Applications:

ELISA, WB

Recommended dilution:

WB: 1:200-1:2000

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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Email: info@sobekbio.com

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