Background:

Possesses 5'->3' exoribonuclease activity(By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II(RNAp II) transcription termination R-loops formed by G-rich pause sites(PubMed:21700224).

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

XRN2, DHM1 like protein, DHP protein, 5' 3' exoribonuclease 2, 5 3 exoribonuclease 2

Specificity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

5'-3' exoribonuclease 2

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

100 kDa, Observed 100 kDa, 55 kDa

Form:

liquid

Applications:

ELISA, WB

Recommended dilution:

WB: 1:200-1:1000

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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